Journal's Scope

Chronic Disease Management & Subhealth Intervention (CDMSI) is a peer-reviewed journal focusing on the fast publication of novel concept, methods, instruments, and regimens for detection, intervention, and prevention of human subhealth conditions and chronic diseases, such as cancer, hypertension, diabetes, arthritis, obesity, COPD, and metabolic syndrome, which affect 25% of the world population and consume 75% of the medical expenditure. The following types of articles are particularly welcomed.
  1. Original research and short research communication
  2. Review and mini-review
  3. Novel medical hypothesis
  4. Novel therapeutic protocols
  5. Novel research methods
  6. New equipment, reagents, and biomarkers
  7. Commentary and letter to the editor –in-chief
  8. Author-initiated special issues
Journal's 4-A-Features
  1. An author-friendly manuscript submission system
    • The online submission process can be completed within 5-7 minutes
    • CDMSI encourages authors to choose their preferred format for manuscript submission
    • CDMSI encourages authors to make the design and display for their accepted papers
    • CDMSI provides free language editing to authors who’s native language is not English
  2. A fast review and publication process
    • A decision for the submission can be made within 3-weeks after the reception by CDMSI
    • Major grant-supported manuscripts can be published within 2-weeks after the submission
    • Authors can request publication of rejected papers with reviewers' comments for debate
    • CDMSI publishes selective articles in both English and Chinese side-by-side
  3. A strong sponsorship and wide readership
    • CDMSI is sponsored by the International Union for Difficult-to-treat-Diseases (IUDD;, a non-profit international medical organization closely associated with medical professionals, patients, pharmaceutic and biologic manufacturers, researches, and governmental officers.
    • CDMSI is also sponsored by Chinese National Center of Colorectal Diseases, 3rd Affiliated Hospital of Nanjing Chinese Medical University, and Nanjing Health Bureau, China, an internationally known institute for its significant contributions to detection, intervention, and prevention of colorectal cancer
  4. Academic and financial awards to top-cited publications and promising projects
    • The top 5-most cited papers of the year will receive an academic certificate from IUDD and CDMSI
    • The corresponding author of the top 3-most cited papers will receive financial assistance to attend IUDD annual conference
    • Promising therapeutics or methodologies will be posted at the website of IUDD
    • Promising initiatives with significant scientific and clinical applications may receive financial support from IUDD
Editor-in-chief’s Short Profile

Dongbo Liu, PhD
Director, United Nations Economic and Social Commission for Asian and the Pacific
Asian-Pacific Consortium for Subhealth Intervention Technology
Director, Chinese State Key Laboratory of Subhealth Intervention Technology Changsha, Hunan, China
Phone & Fax: 8613907482387; 8673184635293;

Dr. Liu is in the vanguard of the application of System Biology in subhealth research, including genomics, metabolomics, proteomics et al. [1-3], . He is also focusing on management of metabolic syndrome specially diabetes [4-6]. His theory covers the molecular mechanism, diagnosis and intervention technology of subhealth as well as chronic disease.

  1. Liu D et al. GC-MS-based metabolic profiling reveals metabolic changes in anaphylaxis animal models. Analytical and Bioanalytical Chemistry, 2012, 404(3)2012 887-893.
  2. Liu D et al. The genome of ganoderma lucidum provide insights into triterpenes biosynthesis and wood degradation. Plos one, 2012, 7(5): e36146.
  3. Liu D et al. Identification of IFN-gamma and double-stranded (dsRNA) induced genes in pancreatic beta-cells by high-density oligonucleotide arrays. Diabetologia, 2003 46:1641–1657.
  4. Liu D et al. Cytokines induce apoptosis in beta-cells isolated from mice lacking tinducible isoform of nitric oxide synthase (iNOS-/-). Diabetes, 2000, 9(7): 1116-1122.
  5. Liu D et al. Double-stranded RNA cooperates with interferon-gamma and IL-1 beta to induce both chemokine expression and nuclear factor-kappa B-dependent apoptosis in pancreatic beta-cells: potential mechanisms for viral-induced insulitis and beta-cell death in type 1 diabetes mellitus. Endocrinology, 2002, 143(4): 1225-1234.
  6. Liu D et al. Study on the effect of ginseng saponins in rattus pancreatic β-cells apoptosis. Biological and Pharmaceutical Bulletin, 2012. 36(9): 1568-1573.

Yan-gao Man, MD, PhD
Director, Research Laboratory and International Collaboration, Bon Secours Cancer Institute, Bon Secours Health System, Richmond, VA, USA (with 20-hospitals and over 22,000 medical staff members)
Adjunct Senior Scientist, Hackensack University Medical Center, NJ, USA (one of 100 best US hospitals)
Vice President for Research and Collaboration, South Hospital of Nanjing, Nanjing, China
Visiting Professor, Chinese National Medical Center of Colorectal Diseases, Nanjing, China
Visiting Professor, Hunan Agriculture University, Changsha, China
Consultant, The Health System of the Hunan Province, China
Chairman of the Board and Secretary General
International Union for Difficult-to-treat Diseases (
Editor-in-chief, Journal of Cancer (Established in 2010; Impact factor 2.639)
Phone & Fax: 301-879-0816; 202-308-6317;

Dr. Man’s research is focused mainly on the mechanisms of tumor invasion and metastasis. He is the author of the world most updated theory for tumor invasion[1-2], which has been recognized as more compatible with the existing evidence than the traditional “proteolytic enzyme theory” [3]. He is also the author of the world most updated theory for tumor metastasis [4, 5]. Among existing theories, his theory is the only one that can reasonably explain all major events of tumor metastasis.

  1. Man YG. Focal degeneration of aged or injured myoepithelial cells and the resultant auto- immunoreactions are trigger factors for breast
  2. tumor invasion. Medical Hypotheses 69(6):1340-1357, 2007.
  3. Man YG, et al. Tumor-infiltrating immune cells promoting tumor invasion and metastasis: Existing theories. J Cancer. 4(1): 84-95, 2013
  4. Pandey PR. Et al. (2011) Role of myoepithelial cells in breast tumor progression. Front Biosci, 15, 226–236, 2011.
  5. Man YG, et al. Leukocyte–facilitated tumor dissemination: findings from multiple types of human tumors. J Cell Chem.112(4):1154- 1167, 2011.
  6. Man YG, et al. Contributions of leukocytes to tumor invasion and metastasis: the “piggy-back” hypothesis. Cancer Epidem 34(1): 3-6, 2010.